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Table 3 Comparison of the blood flow-glucose metabolism parameters in patients with Estrogen Receptor /Progesterone Receptor/ c-erbB2 negative-positive, Triple negative-Non-triple negative and Ki67 1+ and 2+ breast cancer

From: Evaluation of blood supply and metabolism in tumor, axillary lymph node and normal breast tissue with F-18 FDG PET/CT in breast cancer: comparison with pathological prognostic factors

 

glucose metabolism (m) parameters of F-18 FDG PET/CT

Histologic parameters

TV

median (IR)

T-SUVmax

median (IR)

TACm

median (IR)

NG-SUVmax

median (IR)

NGACm

median (IR)

iLN-SUVmax

median (IR)

iLNACm

median (IR)

ER

+

5,76 (7,72)

7,7 (9,7)

9932 (9559)

1,5 (0,55)

1632 (1423)

3,7 (6,9)

4210 (9311)

–

9,84 (24,12)

6,5 (6,85)

14,960 (15257)

1,4 (0,73)

1474 (2014)

5,6 (15,55)

5883 (21220)

p

0,044*

> 0,05

0,041*

> 0,05

> 0,05

> 0,05

> 0,05

PR

+

4,80 (6,75)

5,9 (6,9)

8932 (9708)

1,5 (0,55)

1520 (1358)

3,7 (6,35)

4210 (5828)

–

8,88 (1783)

7,2 (7,5)

13,033 (14223)

1,4 (0,78)

1475 (1883)

4,7 (12,0)

5856 (18383)

p

0,019*

> 0,05

> 0,05

0,043*

> 0,05

> 0,05

> 0,05

c-erbB2

+

6,96 (17,96)

6,8 (7,93)

10,547 (8806)

1,6 (0,68)

1709 (1547)

3,95 (12,93)

5671 (20145)

–

6,44 (7,46)

6,85 (7,13)

12,030 (9323)

1,5 (0,6)

1475 (1743)

3,6 (7,38)

3770 (9865)

p

> 0,05

> 0,05

> 0,05

> 0,05

> 0,05

> 0,05

> 0,05

Tr

TrN

12,8 (41,34)

9,8 (14,4)

20,629 (12580)

1,0 (0,75)

1475 (1818)

5,15 (10,4)

5637 (17207)

nTrN

6,24 (7,86)

6,45 (6,73)

10,137 (8944)

1,5 (0,50)

1576 (1700)

3,7 (7,98)

4422 (11021)

p

> 0,05

> 0,05

0,011*

> 0,05

> 0,05

> 0,05

> 0,05

Ki-67

1+

6,08 (7,36)

6,1 (5,7)

11,998 (10098)

1,7 (0,7)

1431 (1748)

2,4 (2,4)

2608 (3832)

2+

6,64 (12,4)

6,9 (7,4)

10,752 (9336)

1,5 (0,70)

1520 (1837)

5,6 (10,4)

5485 (16927)

p

> 0,05

> 0,05

> 0,05

> 0,05

> 0,05

0,02*

> 0,05

Histologic grade

low

6.08 (10.74)

5.70 (5,13)

112,030 (9608)

1.50 (0.70)

2061 (1631)

3.60 (9.50)

4422 (14145)

high

6.52 (8.06)

8,95 (7,15)

12,450 (10716)

1.50 (0.65)

1181 (1376)

4.20 (8.33)

5252 (8887)

p

> 0,05

0.048*

> 0,05

> 0,05

0,003*

> 0,05

> 0,05

  1. TV tumor volume, ER estrogen receptor, PR progesterone receptor, c-erbB2 human epidermal growth factor receptor 2, Tr Triple, TrN triple negative, nTrN non triple negative, Ki-67 1+ <%14, negative and weakly positive, Ki-67 2+ ≥ %14, strongly positive, m metabolism, T tumor, NG normal breast gland, iLN ipsilaterally lymh node, ACm activity concentration metabolism, SUVmax maximum standardized uptake value, IR interquartile range