Table 4 Performance of dynamic spectral imaging color map in identifying high-grade cervical dysplasia (CIN2 +)
Final histological outcome from four cervical punch biopsies | DSI color code compared to DSI-directed biopsy | DSI color code compared to final histological diagnosis |
|---|---|---|
All referrals | ||
Sensitivity | 48.1% (95% CI 41.1–55.1) | 42.5% (95% CI 36.7–48.5) |
Specificity | 77.0% (95% CI 72.0–81.4) | 78.5% (95% CI 72.8–83.5) |
PPV | 57.5% (95% CI 51.4–63.3) | 70.1% (95% CI 64.0–75.6) |
NPV | 69.6% (95% CI 66.56–72.5) | 53.5% (95% CI 50.5–56.5) |
LG referrals | ||
Sensitivity | 44.1% (95% CI 32.1–56.7) | 37.3% (95% CI 27.9–47.4) |
Specificity | 79.0% (95% CI 72.8–84.4) | 79.5% (95% CI 72.7–85.3) |
PPV | 41.1% (95% CI 32.4–50.4) | 52.1% (95% CI 42.4–61.6) |
NPV | 81.0% (95% CI 77.3–84.2) | 68.0% (95% CI 64.2–71.5) |
HG referrals | ||
Sensitivity | 50.0% (95% CI 41.4–58.6) | 45.4% (95% CI 38.1–52.9) |
Specificity | 73.3% (95% CI 64.3–81.1) | 76.1% (95% CI 64.5–85.4) |
PPV | 69.3% (95% CI 61.6–76.1) | 83.2% (95% CI 76.0–88.5) |
NPV | 54.8% (95% CI 49.9–59.7) | 34.8% (95% CI 30.8–39.2) |