Table 2 Geometric mean plasma levels3 of E2, FSH, P4 and SHBG according to use of HRT among postmenopausal women
E2 dosage category | E2 ¤ nmol/L | FSH¶ IU/L | P4 nmol/L | SHBG‡ nmol/L | |
|---|---|---|---|---|---|
n | 95% CI | 95% CI | 95% CI | 95% CI | |
No HRT | 2651 | 0.07 (0.06–0.07) | 69.6 (65.9–73.5) | 0,82 (0.76–0.89) | 42.4 (40.2–44.8) |
HRT | |||||
HRT without E2 | 20 | 0.07 (0.06–0.08) | 53.4 (44.0–64.9) | 0,65 (0.49–0.87) | 34.9 (28.7–42.4) |
Vaginal E2 | 5 | 0.07 (0.05–0.10) | 70.4 (47.8–104) | 0,99 (0.56–1.76) | 33.4 (22.6–49.4) |
Patches | 9 | 0.15 (0.12–0.19) | 36.4 (27.3–48.5) | 1,05 (0.68–1.61) | 47.0 (35.1–62.8) |
Oral 1 mg | 232 | 0.23 (0.20–0.27) | 36.9 (30.6–44.6) | 0,46 (0.35–0.60) | 52.1 (43.4–62.5) |
Oral 2 mg | 9 | 0.29 (0.22–0.38) | 18.7 (14.1–25.0) | 0,79 (0.51–1.21) | 62.5 (46.8–83.6) |
ANCOVA3 | p < 0.01 | p < 0.01 | p < 0.01 | p < 0.01 |